Our skin can prematurely begin to age by external influences like sunlight, stress, environmental pollution or nicotine. EuRho®Vital Q10 Plus 30® containing 30 mg Coenzyme Q10 can prevent this aging process. The Coenzyme Q10 in the capsules is a natural antioxidant and neutralizes cell-damaging “free radicals” – it can provide new energy to your skins own metabolic processes.
1. General information about Q10:
Ubiquinone, or coenzyme Q (CoQ), was discovered in 1957 by Fred Crane. Coenzyme Q10 or CoQ 10 is a vitamin or vitamin like substance. Like other vitamins, it is found naturally in foods. It is found in a wide variety of foods, in fact, but in small amounts. It is also synthesized in all tissues. This synthesis, which is called biosynthesis, is a multistage process which requires at least eight vitamins and several trace elements. Coenzyme Q10 is fat-soluble. It is present in every cell of the body, and serves as a coenzyme for many of the important enzymatic steps in the production of energy inside the cell. The highest concentrations found in the body are in liver, heart, muscle, kidney, and brain. Another function is as an antioxidant which has clinical effects, hence it is important. As mentioned earlier, coenzyme Q10 is present in a wide variety of foods, being present in particularly high amounts in organ meats such as heart, kidney and liver as well as in beef, oil, sardines, soy, peanuts and mackerel.
The body’s synthesis of the vitamin and intake of it maintain normal levels in the body of a healthy individual. potential role of coenzyme Q10 in the treatment of acquired immunodeficiency syndrome (AIDS), cancer, periodontal disease, gastric ulceration, obesity, muscular dystrophy, allergy, immune function and physical performance has been studied.
Coenzyme Q10 (CoQ10) is produced by the human body and is necessary for the basic functioning of cells. CoQ10 levels are reported to decrease with age and to be low in patients with some chronic diseases such as heart conditions, muscular dystrophies, Parkinson's disease, cancer, diabetes, and HIV/AIDS. Some prescription drugs may also lower CoQ10 levels.
Energy production
The conversion of energy from carbohydrates and fats to adenosine triposphate (ATP), the form of energy used by cells, requires the presence of coenzyme Q in the inner mitochondrial membrane. As part of the mitochondrial electron transport chain, coenzyme Q accepts electrons from reducing equivalents generated during fatty acid and glucose metabolism and then transfers them to electron acceptors. At the same time, coenzyme Q transfers protons outside the inner mitochondrial membrane, creating a proton gradient across that membrane. The energy released when the protons flow back into the mitochondrial interior is used to form ATP.
Proper cell functioning
Lysosomes are organelles within cells that are specialized for the digestion of cellular debris. The digestive enzymes within lysosomes function optimally at an acid pH, meaning they require a permanent supply of protons. The lysosomal membranes that separate those digestive enzymes from the rest of the cell contain relatively high concentrations of coenzyme Q10. Recent research suggests that coenzyme Q10 plays an important role in the transport of protons across lysosomal membranes to maintain the optimal pH.
Powerful Antioxidant
In its reduced form, ubiquinol, CoQ serves as an antioxidant in both mitochondria and lipid membranes by scavenging free radicals. CoQ10 also inhibits lipid peroxidation in biological membranes and in low-density lipoprotein (LDL). It also protects membrane proteins against oxidative damage. CoQ is the only fat-soluble antioxidant that is synthesized in our bodies. In humans ubiquinone-10 (CoQ10, containing 10 isoprenoid units) is the major form.
Sufferers Inflammation is implicated in almost all diseases and especially cardiovascular diseases. The brain is also particularly impacted by inflammation and oxidative stress. Without healthy blood flow from the heart, the brain suffers. Brain cells subjected to excessive oxidative stress over time will die and cannot be replaced.
Improve Neurodegenerative problems
Oxidation in the brain is possibly implicated in neurodegenerative diseases such as Parkinson’s, ALS and Alzheimer’s. CoQ10 plays an important role as it is a player in reducing C Reactive Protein (CRP), an inflammatory marker. About two-thirds of the brain is composed of fats. Myelin, the protective sheath that covers communicating neurons, is composed of 30% protein and 70% fat. While little research exists, the lipophilic nature of CoQ10 and its proven benefits in other neurodegenerative diseases suggest it may be important to research its benefits in Multiple Sclerosis (MS) and its effects on repair of the myelin sheath.
Administering Coenzyme Q10 has also shown positive effects on patients suffering from Parkinson s disease. Other studies suggest that administering CoQ10 can has positive effects on migraine headaches.
Skin health
Coenzyme q10 is critical for skin Health , including melanoma and topical cosmetic use. Also recent research suggests that topically applied CoQ10 may protect the skin against photo aging, or skin aging caused by exposure to ultraviolet light.
German scientists demonstrated that topically applied CoQ10 penetrates the skin’s surface to the living layers of the epidermis, where it reduced oxidative stress. They also noted a marked reduction in the depth of wrinkles following the application of CoQ10. Scientists in Italy have found that CoQ10 may play a significant role in deterring the growth of skin cancer cells.
Anti cancer property
CoQ10 levels also are significantly lower in melanoma patients who developed metastases than in metastasis-free patients. These results suggest that measuring CoQ10 levels may help determine whether an individual’s melanoma is likely to metastasize. By the mid-1960s, Japanese researchers recognized that CoQ10 concentrated in the myocardium, or heart muscle.
Cardiovascular health
Co Q10 role in the heart makes sense: the heart, one of the body's most energetic organs, beats approximately 100,000 times a day and 36 million times a year, and depends on CoQ10 for "bioenergetics." CoQ10 is best documented in the treatment of heart failure.
Gene Regulation
Scientific findings indicate a prominent role of CoQ10 as a potent gene regulator. The presently identified comprehensive list of genes regulated by CoQ10 may be used for further studies to identify the molecular mechanism of CoQ10 on gene expression.
Enhance Immune function
The role of CoQ10 in enhancing immune system is vital, because coQ10 improves immune function in individuals with immune deficiencies (such as acquired immunodeficiency syndrome or AIDS) and chronic infections (such as yeast, bacteria, and viral infections)
Diabetes
CoQ10 supplements may improve heart health and blood sugar and help manage high cholesterol and high blood pressure in individuals with diabetes. High blood pressure, high cholesterol, and heart disease are all common problems associated with diabetes. Despite some concern that CoQ10 may cause a sudden and dramatic drop in blood sugar (called hypoglycemia), two recent clinical studies of people with diabetes given CoQ10, 200 mg 2 times daily, showed no hypoglycemic response.
Improve Athletic Performance
Although coenzyme Q10 supplementation has improved exercise tolerance in some individuals with mitochondrial encephalomyopathies, there is little evidence that it improves athletic performance in healthy individuals.
High cholesterol
Levels of CoQ10 tend to be lower in people with high cholesterol compared to healthy individuals of the same age. In addition, certain cholesterol-lowering drugs called statins (such as atorvastatin, cerivastatin, lovastatin, pravastatin, simvastatin) appear to deplete natural levels of CoQ10 in the body. Taking CoQ10 supplements can correct the deficiency caused by statin medications without affecting the medication's positive effects on cholesterol levels.
Coenzyme Q10 is normally produced by the human body, although deficiency may occur in patients with impaired CoQ10 biosynthesis due to severe metabolic or mitochondrial disorders, not enough dietary CoQ10 intake, or too much CoQ10 use by the body. Depending on the cause of CoQ10 deficiency, supplementation or increased dietary intake of CoQ10 and the vitamins and minerals needed to produce CoQ10 may be effective.
Decreased plasma levels of coenzyme Q10 have been observed in individuals with diabetes, cancer, and congestive heart failure . Lipid lowering medications that inhibit the activity of HMG-CoA reductase, a critical enzyme in both cholesterol and coenzyme Q10 biosynthesis, decrease plasma coenzyme Q10 levels, although it remains unclear whether this has clinical or symptomatic implications.
Rich sources of dietary coenzyme Q10 include mainly meat, poultry, and fish. Other relatively rich sources include soybean and canola oils, and nuts. Fruits, vegetables, eggs, and dairy products are moderate sources of coenzyme Q10. Approximately 14%-32% of coenzyme Q10 was lost during frying of vegetables and eggs, but the coenzyme Q10 content of these foods did not change when they were boiled.
Vitamin B9 or folic acid, also known as folacin and folate, was first recognized as a dietary essential for chicks in 1938. Later it was found to be essential for other animals and human beings too. It was used clinically in 1945 by T. D. Spies, who found it to be effective in the treatment of anaemias relating to pregnancy and tropical sprue (an intestinal malabsorption condition). These findings were subsequently confirmed. About half of the folic acid stored in the body is in the liver which contains 5 to 15 mg/kg of liver weight. A small amount is excreted in the faeces and urine.
Folic acid, in combination with vitamin B12, is essential for the formation, maturation and multiplication of red blood cells. It is necessary for the growth and division of all body cells, including nerve cells, and for manufacturing a number of nerve transmitters. It also produces nucleic acids, RNA (ribonucleic acid) and DNA (deoxyribonucleic acid), that carry hereditary patterns. It aids in protein metabolism and contributes to normal growth. Folic acid helps in the building of antibodies which prevent and heal infections. It is essential for the health of the skin and hair, and helps to prevent premature graying of the hair.
Folic acid is the single most important nutrient for a pregnant woman and her developing fetus. In fact, eating fresh fruits and vegetables rich in folate, from conception until the due date, is the best policy a woman can adopt to ensure that her pregnancy will be a happy and a healthy one. Folic acid also improves lactation. Deficiency of folic acid causes anaemia which often occurs in pregnant women and children. Serious skin disorders, loss of hair, impaired circulation, a grayish-brown skin pigmentation, fatigue, and mental depression can result from a deficiency of this vitamin. Reproductive disorders such as spontaneous abortions and difficult labour, and a high infant death rate can also be caused by folic acid deficiency. Vitamin B9 deficiency may also lead to loss of libido in males. According to studies, two-thirds of geriatric patients were found to be deficient in folic acid, while one-third of psychiatric patients were also deficient in this vitamin. Lack of folic acid can also lead to dementia.
Almost all the anticonvulsant drugs used in the treatment of epilepsy reduce serum folate concentrations. In addition to anticonvulsants, other drugs such as oral contraceptives, pyrimethamine (an antimalarial), co-trimoxazole (contains a sulphur compound), and ethanol (alcohol) may impair folate metabolism.
Vitamin C is a water-soluble vitamin that is necessary for normal growth and development. Vitamin C is required for the growth and repair of tissues in all parts of your body. It is necessary to form collagen, an important protein used to make skin, scar tissue, tendons, ligaments, and blood vessels.
Vitamin C is essential for the healing of wounds, and for the repair and maintenance of cartilage, bones, and teeth. Vitamin C is one of many antioxidants. Vitamin E and beta-carotene are two other well-known antioxidants. Antioxidants are nutrients that block some of the damage caused by free radicals, which are by-products that result when our bodies transform food into energy.
The build up of these by-products over time is largely responsible for the aging process and can contribute to the development of various health conditions such as cancer, heart disease, and a host of inflammatory conditions like arthritis. Antioxidants also help reduce the damage to the body caused by toxic chemicals and pollutants such as cigarette smoke.
The term vitamin E describes a family of eight antioxidants. Alpha-tocopherol is the only form of vitamin E that is actively maintained in the human body; therefore, it is the form of vitamin E found in the largest quantities in blood and tissues.
Approximately 50 to 85 percent of vitamin E in the diet is absorbed from the gastro-intestinal tract by a mechanism similar to that of other fat-soluble vitamins. It enters the bloodstream via the lymph. The vitamin is stored in all the tissues, and the tissue stores can provide protection against the deficiency of this vitamin for long periods. About one-third of the vitamin is excreted in the bile and the balance is excreted in the urine. The main functions of Vitamin E are to help protect the functioning of cells and the intracellular processes. Vitamin E oxygenates the tissues and reduces the need for oxygen intake markedly.
It is essential for normal reproductory functions, fertility, and physical vigour. It prevents unsaturated fatty acids, sex hormones, and fat-soluble vitamins from being destroyed in the body by oxygen. Vitamin E dilates the capillaries and enables the blood to flow freely into blood-deficient muscle tissue, thus strengthening both the tissues and the nerves supplying them. It dissolves blood clots and also prevents their formation. It does not, however, interfere with the normal clotting of blood. It prevents the formation of excessive scar tissues and in some instances, even melts away unwanted scar tissue. It also promotes urine secretion. Vitamin E is said to be essential for prevention of heart disease, asthma, arthritis, and many other conditions.
When applied topically, vitamin E has been known to improve skin moisturization, softness and smoothness and also provide modest photoprotection. Deficiency of vitamin E may lead to degenerative changes in the blood capillaries which, in turn, can lead to heart and lung disease, pulmonary embolism, and a brain stroke. Deficiency of this vitamin may also lead to loss of sexual potency. A prolonged deficiency may lead to reproductive disorders, abortions, miscarriages, male or female sterility, as well as muscular disorders.
Preliminary research suggests that CoQ10 causes small decreases in blood pressure (systolic and possibly diastolic). Low blood levels of CoQ10 have been found in people with hypertension, although it is not clear if CoQ10 "deficiency" is a cause of high blood pressure. Well-designed long-term research is needed to strengthen this recommendation.
2. Adjunct to statin therapy
Coenzyme Q10 may reduce some adverse effects associated with statin therapy for high cholesterol, including reduced heart function. More study is needed before a recommendation can be made.
3. Age-related macular degeneration
Early study shows that acetyl-L-carnitine, n-3 fatty acids, and Coenzyme Q10 may help age-related macular degeneration. More research is needed using Coenzyme Q10 alone before a recommendation can be made.
4. Alzheimer's disease
Promising preliminary evidence suggests that CoQ10 supplements may slow down, but not cure, dementia in people with Alzheimer's disease. Additional well-designed studies are needed to confirm these results before a firm recommendation can be made.
5. Angina (chest pain from clogged heart arteries)
Preliminary small human studies suggest that CoQ10 may reduce angina and improve exercise tolerance in people with clogged heart arteries. Better studies are needed before a firm recommendation can be made.
6. Asthma
CoQ10 may benefit asthma patients when added to other therapies. Further research is needed. Asthma should be treated by a qualified healthcare provider.
7. Breast cancer
Supplementation with CoQ10 has not been proven to reduce cancer and has not been compared to other forms of treatment for breast cancer.
11. Chronic fatigue syndrome
Early study shows that CoQ10 may improve symptoms of chronic fatigue syndrome. High quality research is needed in this area before a decision can be made.
9. Exercise performance
Results are variable, with some research suggesting benefits, and other studies showing no effects. Most trials have not been well designed. Better research is necessary before a firm conclusion can be drawn.
10. Friedreich's ataxia
Preliminary research reports promising evidence for the use of CoQ10 in the treatment of Friedreich's ataxia. Further evidence is necessary before a firm conclusion can be drawn.
11. Gum disease (periodontitis)
Preliminary human studies suggest possible benefits of CoQ10 taken by mouth or placed on the skin or gums in the treatment of periodontitis. Better research is needed before a strong conclusion can be drawn.
12. Heart attack (acute myocardial infarction)
There is preliminary human study of CoQ10 given to patients within three days after a heart attack. Better research is needed before a firm conclusion can be drawn.
13. Heart failure
The evidence for CoQ10 in the treatment of heart failure is controversial and remains unclear. Different levels of disease severity have been studied (New York Heart Association classes I through IV). Better research is needed in this area studying the effects on quality of life, hospitalization, and death rates before a recommendation can be made.
14. HIV/AIDS
There is limited evidence that natural levels of CoQ10 in the body may be reduced in people with HIV/AIDS. There is a lack of reliable scientific research showing that CoQ10 supplements have any effect on this disease.
There is early evidence that supports the use of CoQ10 in the treatment of increasing sperm count and motility. Better studies are needed before a strong recommendation can be made.
16. Kidney failure
There is initial data to support the use of CoQ10 in the treatment of kidney (renal) failure. More research is needed before a recommendation can be made.
17. Maternally-inherited diabetes and deafness (MIDD)
CoQ10 may help improve function in children with maternally-inherited diabetes and deafness. Further research is needed to confirm these results.
18. Migraine
There is fair evidence to support the use of CoQ10 treatment in migraine prevention or treatment. However, more well-designed studies are needed to confirm these findings.
19. Mitochondrial diseases and Kearns-Sayre syndrome
CoQ10 is often recommended for patients with mitochondrial diseases, including myopathies, encephalomyopathies, and Kearns-Sayre syndrome. Better studies are needed before a strong recommendation can be made.
20. Muscular dystrophies
Preliminary studies in patients with muscular dystrophy taking CoQ10 supplements describe improvements in exercise capacity, heart function, and overall quality of life. Additional research is needed in this area.
21. Parkinson's disease
There is promising human evidence for the use of CoQ10 in the treatment of Parkinson's disease. Better-designed trials are needed to confirm these results.
22. Post-surgical recovery (adjuvant)
In patients with stage I and II melanoma with surgically removed lesions, CoQ10 may decrease the rate of recurrence. Although these results are promising, more study is needed in this area to confirm these conclusions.
23. Prostate cancer
One study using a combination that included CoQ10 did not find a significant effect on PSA levels in patients with prostate cancer. Although PSA levels may be an indicator of cancer, it is unclear whether CoQ10 would have any effect on cancer treatment of prevention. More study is needed.
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